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Updated: Sep 10, 2025

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
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KIR- HLA相互作用による免疫調節は,大腸がんにおけるセトゥキシマブの有効性を影響する

María Gómez-Aguilera1, Bárbara Manzanares-Martín2,3, Arancha Cebrián-Aranda4

  • 1Medical Oncology Department, Reina Sofia University Hospital, University of Cordoba, 14071 Cordoba, Spain.

International journal of molecular sciences
|August 28, 2025
PubMed
まとめ

殺人細胞の免疫グロブリン型受容体 (KIR) とHLAの相互作用は,転移性大腸がん (CRC) のセトキシマブの有効性に大きな影響を与えます. 特定のKIR-HLAプロファイルは,よりよい患者のアウトカムを予測し,CRCのパーソナライズされた治療戦略を導く.

キーワード:
HLA リガンドKIR についてアンチEGFRセトゥキシマブ転移性大腸がん自然殺虫細胞

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