心血管リスクと糖尿病性多神経症における性別差異:ハンガリー北東部の単一センターの遡及研究

Ferenc Sztanek¹, Attila Pető^2,3, László Imre Tóth¹

¹Department of Internal Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.

Journal of clinical medicine

|August 28, 2025

まとめ

糖尿病性感覚運動多神経症 (DSPN) は,同様の血糖制御にもかかわらず,男性においてより一般的です. 女性の性別は,より低いDSPN発生率と関連しており,糖尿病合併症の性別特異性を強調しています.

科学分野:

内分泌学と代謝
神経学
心臓病科

背景:

糖尿病性感覚運動多神経症 (DSPN) は,生活の質に影響を与える糖尿病の一般的な合併症です.
DSPNに関連する性別の心血管リスクに関するデータは限られているが,特に中・東欧の集団では限られている.

研究の目的:

心血管リスクプロファイルとDSPNとの関連性における性別の違いを調査する.
糖尿病患者集団におけるDSPNの独立予測因子を特定する.

主な方法:

1型または2型糖尿病の621人の患者の遡及分析.
症状スコアと電気生理学的測定を含む国際基準に基づくDSPNの診断
多変数ロジスティック回帰は,独立した予測要因を特定します.

主要な成果:

DSPNは患者の71. 5%で診断され,58. 2%が女性でした.
男性は心筋梗塞,外周血管疾患,動脈硬化症の割合が高かった.
女性の性別は独立して低DSPN発生率 (OR=0. 592) と関連しており,糖尿病性網膜症は予測因子であった (OR=2. 728).
電気生理学的検査では,女性の神経伝導幅が低いことが示された.

結論:

性別によって DSPN のリスクに重大な差異がある.
地域特有のリスク要因を考慮して,糖尿病患者の個別化されたスクリーニング戦略が推奨されています.

キーワード:

心血管の危険因子糖尿病性センソモーター多神経症性別の違い 2型糖尿病

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