重度のCOVID-19 疾患における予後指標としてのユータイロイド病症候群

Lambros Athanassiou¹, Ifigenia Kostoglou-Athanassiou², Georgia Kaiafa³

¹COVID-19 Department, Asclepeion Hospital, Voula, 16673 Athens, Greece.

Medicina (Kaunas, Lithuania)

|August 28, 2025

まとめ

甲状腺病症候群は重症のCOVID-19患者の間で多く見られ,予後が悪いことを示します. FreeT3のような甲状腺ホルモンの測定は,入院したCOVID-19患者の結果を予測するのに役立ちます.

科学分野:

内分泌学
感染症
クリティカルケア医療

背景:

非甲状腺疾患症候群 (Euthyroid sick syndrome,ESS) は,重症患者の予後指標である.
ESSは,COVID-19を含む重度の感染症で観察されています.
重度のCOVID-19の予後指標を特定することは,患者の管理に極めて重要です.

研究の目的:

重度のCOVID-19患者でESSを特定する.
ESS,疾患の重症度,患者のアウトカムとの関係を決定する.

主な方法:

重症のCOVID-19患者は甲状腺機能検査 (TSH,FT3,FT4) を受けました.
患者は呼吸機能と酸素濃度 (疾患の重度1- 4) に基づいて4つのグループに分けられました.

主要な成果:

ESSは重症のCOVID-19患者の57.1%で診断されました.
ESSの存在は,疾患の重症度および死亡率の増加と相関する.
自由T3値の低下は,C反応性タンパク質 (CRP) 値の上昇と関連していた.

結論:

ESSは重症なCOVID-19で一般的であり,予後が悪いことに関連しています.
甲状腺ホルモンの測定は,重度のCOVID-19での結果を予測する貴重なツールとして役立つ可能性があります.

キーワード:

コロナウイルス SARS-CoV-2について甲状腺病症候群非甲状腺疾患症候群

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