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Updated: Sep 9, 2025

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Published on: January 7, 2019

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マイクロドロップレシピテーションシステムを用いたカーバマゼピンの2段階核化とアモルフィ化

Xiaoling Zhu1, Cheongcheon Lee2, Ju Hyun Park3

  • 1Department of Chemical Engineering (Integrated Engineering Program), College of Engineering, Kyung Hee University, 1732, Deogyeong-daero, Giheung-gu, Yongin-si 17104, Republic of Korea.

Pharmaceutics
|August 28, 2025
PubMed
まとめ

研究者は新型のマイクロドロップレットシステムを開発し,無形カルバマゼピンを生成し,薬の溶解性を高めました. この方法は,溶解性が低い薬の形状化プロセスに関する洞察を明らかにし,潜在的な医薬品の応用を改善します.

キーワード:
アモルフィケーションカルバマゼピン中間段階液体から液体への移行2段階の核化

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After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...
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Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
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