舌下および口口での出産: 歴史的および科学的な規定
Sina Bahraminejad1, Hassan Almoazen1
1Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Rm 661, Memphis, TN 38018, USA.
Pharmaceutics
|August 28, 2025
まとめ
薬剤のサブリンガルおよび口腔投与は 75年にわたって大きく進化し, 4つの異なる成長期を経た. 現在の研究は 治療効果を高めるために 粘膜の配分を進める研究に焦点を当てています
科学分野:
- 薬理学と医薬品
- 薬物投与システム
- 粘膜による薬物投与
背景:
- 75年以上に渡って 薬のサブリンガル・経路と 口経路が研究されてきました
- 初期の研究 (1950年−1982年) は,これらの粘膜経路の探索が限られていることを示した.
- 特に1980年代以降は,著しい進展がありました.
研究 の 目的:
- 過去75年の言語下および口腔薬剤投与の歴史的発展を振り返る.
- この分野における重要な段階とイノベーションを特定する.
- 粘膜経由による薬剤投与に注目する研究が 増えていることを強調します
主な方法:
- "サブリンガルとブカル"の検索に基づく文献レビュー
- 1950年から2025年の出版動向の分析
- 研究を異なる成長期に分類する.
主要な成果:
- 言語下および口頭での発話に関する研究において,初期 (1950年-1982年),探索期 (1983年-1993年),多様化 (1994年-2009年),イノベーション (2010年-2025年) の4つの異なる成長期を特定した.
- ナノ粒子,粘膜系,小児薬剤を含む治療薬と製剤技術の拡大を記録した.
- 胸痛や高血圧から痛み管理,オピオイド使用障害,ワクチン投与に至るまで,様々な疾患に対する使用が増加していることに留意した.
結論:
- 薬剤のサブリンガル投与と口腔投与は 薬学研究のダイナミックで拡大している分野です
- 薬の効能と患者への従順性の改善の必要性によって 継続的なイノベーションの軌跡が明らかにされています
- 将来の研究は,局所的および全身的な治療結果の両方のために,粘膜による薬物投与をさらに強化する準備ができています.
関連する概念動画
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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01:16Drug Delivery: Overview
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01:22Drug Delivery: Miscellaneous Routes
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