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Updated: Sep 9, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
10:44

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures

Published on: March 28, 2017

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犯人および被害者のサイトクロームP450 2C誘導リスクを評価するための生理学的基礎の薬理学モデリング

Marina Slavsky1, Aniruddha Sunil Karve1, Niresh Hariparsad1

  • 1Drug Metabolism and Pharmacokinetics, Oncology R&D (Research & Development), AstraZeneca, 35 Gatehouse Park Drive, Boston, MA 02451, USA.

Pharmaceutics
|August 28, 2025
PubMed
まとめ

生理学的基礎の薬動学 (PBPK) モデリングは,CYP2C酵素誘導による薬物相互作用 (DDI) を正確に予測します. このアプローチは,DDIのリスクを評価するための機械的静的モデリング (MSM) を改善し,臨床結果と良好に相関しています.

キーワード:
CYP2C誘導DDI についてPBPK についてヘパトサイト薬理学

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