関連する実験動画

Updated: Sep 9, 2025

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

11.9K

タンパク質標的の構造変形に関する情報を抽出するためのマルチコンフォーマーの探索:Bcl-xL標的のイラスト

Marine Baillif1, Eliott Tempez1, Anne Badel1

  • 1Université Paris Cité, CNRS, Inserm, Unité de Biologie Fonctionnelle et Adaptative F-75013 Paris, France.

Molecules (Basel, Switzerland)
|August 28, 2025
PubMed
まとめ

SA-confはタンパク質の骨格構造の変化を定量化します. この方法は,リガンド結合がBcl-xLの構造変化を誘導し,選択的な薬剤設計のための重要なプラスチック領域を特定することを明らかにした.

キーワード:
Bcl-xL についてバックボーン構造の変動性バインディングサイトマッピングリガンドによる形状の変化構造的な保存

さらに関連する動画

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Published on: October 28, 2013

10.9K
Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics14:14

Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics

Published on: April 16, 2017

11.7K

関連する概念動画

Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
215
Plastic Deformations01:14

Plastic Deformations

It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
131
Deformation of a Beam under Transverse Loading01:15

Deformation of a Beam under Transverse Loading

Understanding beam deflection, particularly for indeterminate beams with overhanging segments and multiple concentrated loads, is crucial for ensuring structural integrity and functionality. The process begins with constructing an accurate free-body diagram, which helps identify the forces and moments acting on the beam. This diagram is vital for visualizing how bending moments vary along the beam's length, influencing its curvature.
The insights from the bending moment diagram extend to...
425
Three-Dimensional Analysis of Strain01:29

Three-Dimensional Analysis of Strain

Three-dimensional strain analysis is crucial for understanding how materials deform under stress, particularly in elastic, homogeneous materials. This method employs principal stress axes to simplify complex stress states into more understandable forms. Subjected to stress, a small cubic element within a material either expands or contracts along these axes, transforming into a rectangular parallelepiped. This transformation effectively illustrates the material's deformation. The principal...
289
Transformation of Plane Strain01:12

Transformation of Plane Strain

When analyzing elongated structures like bars subjected to uniformly distributed loads, it is essential to understand the transformation of plane strain when coordinate axes are rotated. This transformation helps to assess how material deformation characteristics vary with orientation, which is crucial in materials science and structural engineering.
Under plane strain conditions, typical for members where one dimension significantly exceeds the others, deformations and resultant strains are...
237