重要な疾患における筋肉機能に対するタンパク質栄養の効果:体系的なレビューとメタ解析
Mohamed A Mohamed1,2, Brett Doleman1,2, Bethan E Phillips1
1Centre of Metabolism, Ageing and Physiology (COMAP), MRC-Versus Arthritis Centre of Musculoskeletal Ageing Research (CMAR) and Nottingham NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Nutrients
|August 28, 2025
まとめ
集中治療室 (ICU) でタンパク質の摂取量を増やすと,骨格筋の強度が向上する可能性があります. 重症患者の筋肉機能に対するこの効果を確認するには,より質の高い試験が必要である.
科学分野:
- クリティカルケア医療
- 栄養学
- 筋肉の生理学
背景:
- 重要な疾患はタンパク質の代謝を変化させ 骨格の筋肉の代謝と機能の低下につながります
- タンパク質栄養は臨床的結果を改善しますが,重症患者の筋肉強度に対する具体的な影響は不明です.
- 筋肉の機能における タンパク質の役割を理解することは 患者の回復を最適化するために 極めて重要です
研究 の 目的:
- 成人集中治療室 (ICU) の患者の骨格筋強度に対するタンパク質の投与量の変化の効果を体系的に検討する.
- 最適なタンパク質戦略を決定するために,ランダム化制御試験 (RCT) の証拠を合成する.
- 重要な病気におけるタンパク質補給と筋肉機能に関する研究のギャップを特定する.
主な方法:
- 5つの主要なデータベースと臨床試験の登録簿で,関連するRCTを体系的に検索する.
- 含有基準: 妊娠していない成人ICU患者,異なるタンパク質用量,筋肉の強さの結果.
- 排除基準:筋肉構造のみの研究または併用介入の研究,5つの適格なRCTのメタ解析
主要な成果:
- タンパク質の摂取量が高いグループと低いグループでは,骨格筋の強さの統計的に有意な差が見られた (平均差は2. 36kg).
- グループ間のタンパク質用量の平均差は0. 46g/ kg/ dでした.
- 含まれた研究は,相当な異質性を示す中等から高いバイアスのリスクを示した.
結論:
- タンパク質の投与量は,ICU患者の骨格筋強度に影響するようです.
- 現在の証拠は,筋肉機能に焦点を当てた試験の数と質によって制限されています.
- 深刻な病気で筋肉の強さを高めるためのタンパク質治療の決定的な推奨を確立するために,さらなる高品質の研究が不可欠です.
関連する概念動画
Overview of Protein Metabolism
1.8K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.8K
Chronic Kidney Disease III: Interprofessional Care
77
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
77
Proteins: Dietary Sources and Requirements
606
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
606
Acute Kidney Injury V: Interprofessional Care
44
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
44
Muscle Recovery and Fatigue
2.5K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.5K
Nephrotic Syndrome I : Introduction
27
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
27


