韓国における潜在的ビタミンD毒性およびその危険因子の増加:人口を基にした大規模な研究
Rihwa Choi1,2, Gayoung Chun3, Sung-Eun Cho4
1Laboratory Medicine Center, Division of Laboratory Medicine, GC Labs, Yongin-si 16924, Republic of Korea.
Nutrients
|August 28, 2025
まとめ
韓国では,特に女性や高齢者の間で,ビタミンD (25-ヒドロキシビタミンD) のレベルが上昇しています. この傾向は,潜在的なビタミンDの毒性を防ぐために,より高い意識とモニタリングを必要とする.
科学分野:
- 内分泌学
- 公衆衛生
- 栄養学
背景:
- ビタミンDは 免疫機能,骨の健康,心臓血管の健康,癌の予防に不可欠です
- 韓国における血清25-ヒドロキシビタミンD [25-OH) D]の上昇の発生率と危険因子に関するデータは限られている.
- 25 ((OH) Dの値が上昇すると,ビタミンDの潜在的毒性を示す可能性があります.
研究 の 目的:
- 韓国における血清25 (OH) D濃度の上昇の流行と傾向を調査する.
- 潜在的なビタミンD毒性に関連した人口統計学的および時間的リスク要因を特定する.
主な方法:
- 2020年から2022年の間に検査された1,198,947人の検査データの遡及分析.
- 潜在的ビタミンD毒性の定義は,血清25 ((OH) Dレベル> 50,100,または150ng/mLである.
- 多変数ロジスティック回帰分析による年齢,性別,月,年別での流行の調査.
主要な成果:
- 血清25 ((OH) D>50ng/mLの流行率は4. 41% (2020) から6. 21% (2022) に増加した.
- 血清25 ((OH) D>100ng/mLの罹患率は0. 09%から0. 12%に増加した.
- 女性,子供 (0~9歳),成人 (≥50歳) でより高い罹患率を観察した.
結論:
- ビタミンDの毒性の流行は低いが,継続的な上昇傾向が見られる.
- 公衆の意識を高め,臨床モニタリングを行い,ガイドラインに基づく補給が必要である.
- ビタミンD中毒を防ぐために,高齢者層に特に注意を払うべきです.
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