ナリンギンの内皮および心血管への影響: 系統的レビュー

Jose A Adams¹, Arkady Uryash^1,2, Alfredo Mijares³

¹Division of Neonatology, Mount Sinai Medical Center, Miami, FL 33140, USA.

Nutrients

|August 28, 2025

まとめ

ナリンジンは類のフラボノイドであり,内皮機能を改善し,イシュケミア再注射による損傷から保護することで,心臓血管に重要な効果を示しています. 心臓の健康のために最適な使用を確認するには,さらなるヒト試験が必要です.

科学分野:

心血管研究
栄養科学
薬理学について

背景:

リンゴに多く含まれているフラボノイドであるナリンジンは心血管の健康に重要な化合物として登場しています
血管機能と心臓の保護に関して過去20年にわたってその潜在的利点が調査されています

研究の目的:

内皮機能と心筋機能に対するナリンギンの影響を体系的に検討する.
ナルリンジンのイシュケミア-再注射 (I/R) 損傷への影響を評価する.
2000年から2025年の間に発表された細胞,動物,ヒトの研究結果を統合する.

主な方法:

PRISMA 2020のガイドラインに沿った体系的なレビューです.
PubMed,Scopus,EMBASE,Web of Scienceで幅広い文献を検索しました
バイアス評価のリスクのある62件の研究 (細胞,動物,ヒト) を含む.

主要な成果:

ナリングンは抗酸化,抗炎症,血管保護効果を一貫して示した.
PI3K/Akt,NF-κB,Nrf2,RAS経路の調節,そして細胞死経路の阻害が含まれています.
動物実験では血管緩解が改善され,心臓発作の大きさが減少した.ヒト試験では,脂質プロフィールと動脈の硬化が改善された.

結論:

ナリンジンは,心臓血管の保護のための栄養補助食品として,特に不血性損傷に対する重要な可能性を示しています.
血管保護性および抗アポプト性性は,メカニズム学および臨床前データによって支持されています.
最適な投与量を確立し,ヒトでの生物利用性を高めるために,さらなる臨床試験が不可欠です.

キーワード:

心血管疾患内皮機能フラボノイド血栓不全の再注射心筋の保護ナリング栄養薬酸化ストレス

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