IBD 患者における栄養状態,微量栄養素欠乏,および疾患活動との関連:多センター横断研究
Marco Valvano1,2, Susanna Faenza1, Fabio Cortellini3
1Gastroenterology, Hepatology and Nutrition Division, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Nutrients
|August 28, 2025
まとめ
鉄とビタミンDのレベルを含む栄養状態は,炎症性腸疾患 (IBD) の活動と相関しています. しかし,これらのマーカーは,IBD患者における活性疾患と非活性疾患の区別において最適でない正確性を示した.
科学分野:
- 胃腸内科
- 臨床栄養について
- 免疫学
背景:
- 炎症性腸疾患 (IBD) は,炎症によって特徴づけられる慢性腸疾患である.
- 炎症状態は 栄養不足と 粘膜損傷による栄養吸収の低下につながる.
- 栄養状態と病気の活動との関係を理解することは,患者の管理に極めて重要です.
研究 の 目的:
- 微量栄養素欠乏を含む栄養状態とIBD患者の疾患活動との関係を評価する.
- 栄養のパラメータに関連した疾患活動の臨床的および実験的マーカーを評価する.
- 活性IBDの潜在的な栄養指標を特定する.
主な方法:
- イタリアの3つのセンターで実施された横断的な研究.
- 基礎データ,臨床疾患の活動,検査結果の収集
- 評価された微量栄養素 (鉄,フェリチン,ビタミンB12,ビタミンD,葉酸),ヘモグロビン,およびアルバミン.
- ピアソン・コレレーションと受信機の運用特性 (ROC) の分析を採用した.
主要な成果:
- 110人のIBD患者 (40人のクローン病,70人の潰瘍性大腸炎) を分析した.
- ヘモグロビン,鉄,フェリチン,ビタミンDのレベルは,活性疾患群と非活性疾患群の間で有意に異なった (p < 0. 007).
- 鉄とビタミンDはROC分析において最も高い精度を示した (AUCはそれぞれ0. 76と0. 68) が,最適以下であった.
結論:
- ヘモグロビン,鉄,フェリチン,ビタミンDはIBDの活動と関連しています.
- これらのマーカーは,活発な疾患と非活発な疾患を区別する上で最適でない精度を示しています.
- 葉酸,ビタミンB12,およびアルブミンは,疾患の活動状態と相関性が低いことが示された.
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