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Updated: Sep 9, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

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GLP-1アゴニストを超えて:肥満管理における代謝適応に対抗するための適応性ケトゲン-地中海プロトコル

Cayetano García-Gorrita1, Nadia San Onofre2, Juan F Merino-Torres3,4,5

  • 1Food & Health Lab, Institute of Materials Science, University of Valencia, 46980 Paterna, Spain.

Nutrients
|August 28, 2025
PubMed
まとめ

アダプティブ・ケトジェニック・メディテレーニアン・プロトコル (AKMP) は 栄養とバイオマーカーの調整を組み合わせることで 肥満の長期的な管理に新たなアプローチを提案しています

キーワード:
GLP-1受容体アゴニスト適応性発熱ダイナミック・ダイエット・プロトコルケトゲン系地中海ダイエット代謝適応栄養ケトーシス肥満管理パーソナライズされた栄養減量維持

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Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
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Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Metabolic States of the Body: The Absorptive State01:25

Metabolic States of the Body: The Absorptive State

During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
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