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Updated: Sep 9, 2025

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
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The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

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共通群の多様性:グラム陰性病原体からのクラスDβ-ラクタマゼの構造的洞察

Clyde A Smith1,2, Anastasiya Stasyuk1,3

  • 1Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.

Pathogens (Basel, Switzerland)
|August 28, 2025
PubMed
まとめ

クラスD β-乳糖酵素 (DBL) は,カルバペネムのような薬物を分解することで,抗生物質の有効性を脅かします. そのBループはPループと Ωループとともに,グラム陰性細菌の酵素活性とカルバペネマース機能に重大な影響を及ぼします.

キーワード:
抗生物質に対する耐性カルバペネマースグラムネガティブ構造的ダイナミクスβ-ラクタマース

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