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Updated: Sep 9, 2025

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α-ケトグルタレットは,mTOR経路の調節により,酸化ストレス誘発ニューロン老化を弱める

Ruoqing Guan1,2, Zhaoyun Xue1,2, Kaikun Huang3,4

  • 1National and Local United Engineering Lab of Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Pharmaceuticals (Basel, Switzerland)
|August 28, 2025
PubMed
まとめ

アルファケトグルタレート (AKG) は,mTORシグナル伝達を抑制し,ミトコンドリア機能を強化することで,酸化ストレスによるニューロン老化を軽減します. この代謝介入は 老化による神経変性疾患の治療に 有望な結果を示しています

キーワード:
D-ガラクトースH2O2 についてTCAアルファケトグルタレート脳の老化mTOR についてプロテオミック

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