関連する実験動画

Updated: Sep 9, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

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抗菌剤耐性との闘い:ペプチド,ナノテクノロジー,ファージ,クオラムセンシング,CRISPR-Casシステムを用いた革新的な戦略

Ana Cristina Jacobowski1, Ana Paula Araújo Boleti1, Maurício Vicente Cruz1,2

  • 1Protein Purification and Biological Functions Laboratory, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul (UFMS), P.O. Box 549, Campo Grande 79050-010, MS, Brazil.

Pharmaceuticals (Basel, Switzerland)
|August 28, 2025
PubMed
まとめ

エンジニアリングされたペプチド,ナノ粒子,CRISPR-Casシステムなどの革新的な戦略は,増える抗菌剤耐性 (AMR) に対して新しい希望を提供します. このレビューでは,耐性感染症と闘うための有望な治療方法と,将来の薬物開発の指針を詳細に述べています.

キーワード:
抗菌ペプチドバイオフィルムの破壊併用療法薬物投与システム多剤耐性

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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