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Updated: Sep 9, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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リウマチ性関節炎シノビオサイトにおけるPI3K/ AKT/ mTOR経路の薬理学的抑制:体系的レビューとメタ解析 (臨床前)

Tatiana Bobkova1,2, Artem Bobkov3, Yang Li1,4

  • 1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Pharmaceuticals (Basel, Switzerland)
|August 28, 2025
PubMed
まとめ

PI3K/ AKT/ mTOR経路を標的にすると,リウマチ性関節炎における線維細胞のようなシノビオサイト増殖と炎症が著しく減少します. この経路は有効な治療目標であり,p- AKTとp- mTORは重要な応答マーカーとして機能する.

キーワード:
PI3K/AKT/mTOR についてサイトカイン線維細胞のようなシノビオサイトインビトロモデルメタ解析p-AKTp-mTOR について経路の阻害リウマチ性関節炎体系的なレビュー

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