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Updated: Sep 9, 2025

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia
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MAPT/tau-secretory lysosomesの障害は,アルツハイマー病患者の認知的脆弱性に関連している

Preeti Sharma1,2, Anuma Pallavi3, Ananya Chatterjee4,5

  • 1Center for Brain Research, Indian Institute of Science, Bangalore, India.

Autophagy
|August 28, 2025
PubMed
まとめ

ライソーム機能障害は,タウタンパク質の拡散を可能にすることで,アルツハイマー病 (AD) 認知症の進行を促します. リソーム外細胞症を標的とした治療は,AD患者の認知回復力を回復させる可能性があります.

キーワード:
アルツハイマー病認知回復力認知的な脆弱性リソソーム性別の違いタウ病理

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