[細胞のカルシウムフリュース信号に基づく5ヒドロキシトリプタミン2A受容体を標的とする薬物の高通量スクリーニング方法の確立と適用]

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...