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Updated: Sep 9, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

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15-デオキシ-Δ12,14-プロスタグランジンJ2は,ヒトのマイクロ血管内皮細胞 (HMEC-1) でアポトーシスを誘導する

Hwa-Young Lee1,2, Young Il Kim3, Misong Kim4

  • 1Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul, 02447 Republic of Korea.

Toxicological research
|August 28, 2025
PubMed
まとめ

15- デオキシ- Δ J2 (15d- PGJ2) は,ヒトの微小血管内皮細胞の成長とコロニー形成を阻害する. この化合物はまたアポトーシスを誘導し,NF-κBとPI3K/AKT/mTOR経路を抑制することによって細胞サイクル遺伝子発現を調節する.

キーワード:
15-デオキシ-Δ12,14-プロスタグランディンJ2アポトーシス細胞サイクルサイクリン依存キナーゼ人間の微血管内皮細胞

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