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Updated: Sep 9, 2025

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
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Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

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シングル・ヌクレオチド・ポリモルフィズムに基づくオピオイド鎮痛剤の個別化使用に関するケース・コントロール研究

Jing Yang1,2, Lei Zheng1, Fu Zheng2

  • 1Department of Pharmacy, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Frontiers in pharmacology
|August 28, 2025
PubMed
まとめ

OPRM1の遺伝的変異は,オピオイド鎮痛剤を服用している患者の副作用の増加と関連しています. 安全性と有効性を高めるために,特にOPRM1 AA遺伝子型キャリアに対して,個別化された薬剤戦略が必要である.

キーワード:
薬の副作用薬物用量需要オピオイド鎮痛剤パーソナライズされた薬シングルヌクレオチドポリモルフィズム

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