ナノ材料によるがん治療における腫瘍微生物群の標的化

Yanan Niu¹, Junya Feng¹, Jie Ma²

¹State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences Peking Union Medical College Beijing P. R. China.

Exploration (Beijing, China)

|August 28, 2025

まとめ

腫瘍内微生物群 (TME) が癌の進行を促しますナノテクノロジーは癌を誘発する微生物を標的とし有効な治療法を提案しています

科学分野:

腫瘍学
微生物学
ナノテクノロジー

背景:

腫瘍内微生物群は,腫瘍の微環境 (TME) の構成要素であり,がんに大きな影響を与える.
腫瘍に関連する微生物に関する理解は,技術的な課題のために限られていた.
ハイ・スループット・シーケンシングは腫瘍内の異質な微生物群を明らかにした.

研究の目的:

癌の進行における腫瘍内微生物群の役割を検討する.
腫瘍に関連する微生物を標的とするナノテクノロジーベースの戦略を探求する.
これらの抗がんアプローチの臨床的意義と課題について議論する.

主な方法:

腫瘍内微生物群と癌に関する現在の文献のレビュー.
腫瘍に関連した微生物によって媒介されるがん前メカニズムの分析
微生物を標的とするがん治療におけるナノテクノロジーの応用に関する検討

主要な成果:

腫瘍内微生物はDNA損傷,発がん性経路,免疫抑制によって癌に寄与する.
ナノテクノロジーは,TME内の微生物の相互作用を制御する可能性を示しています.
新興戦略は,微生物群を標的とした抗腫瘍療法のためにナノテクノロジーを活用しています.

結論:

腫瘍内微生物群は癌の発生と進行の重要な要因である.
ナノテクノロジーは腫瘍の微生物群を調節する新しい治療法を示しています
臨床的な課題に対処し,これらの発見を有効ながん治療法に変換するには,さらなる研究が必要です.

キーワード:

抗菌剤腫瘍内微生物群ナノ材料腫瘍治療

さらに関連する動画

09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K

14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.8K

関連する概念動画

02:17

The Tumor Microenvironment

6.8K

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

6.8K

02:57

Targeted Cancer Therapies

7.8K

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

7.8K

01:27

Tumor Immunotherapy

659

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

659

01:15

Drugs that Stabilize Microtubules

2.1K

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

2.1K

02:49

Cancer Therapies

7.9K

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

7.9K

01:10

Drugs that Destabilize Microtubules

2.0K

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...