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Updated: Sep 9, 2025

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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オートファジー,ハンティントン病,およびそれ以上の場合におけるS-アサイレーションによるセクステストソーム1の分離

Y Alshehabi1, F Abrar1, D D O Martin1

  • 1Department of Biology, University of Waterloo, Waterloo, ON, Canada.

Autophagy reports
|August 28, 2025
PubMed
まとめ

タンパク質S-アシレーションは,SQSTM1をリソソームに誘導することによって,オートファギーを調節する. ハンチントン病におけるS-アサイレーションの減少はタンパク質クリアランスを低下させ,S-アサイレーションが神経変性における治療標的であることを示唆する.

キーワード:
オートファジーハンティントン病S-アシレーション断食するハンティングチン地元化マウスモデルパルミトイレーションパルモスタチンBシーケストソーム1

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