COVID-19の治療のための吸入性窒素酸化物:オープンラベル,並行,ランダム化制御試験
Frederico Friedrich1,2, Marcelo Cypel3, Vinicius Schenk Michaelsen3
1Centro Infant, Department of Pediatrics, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
ERJ open research
|August 28, 2025
まとめ
高濃度の吸入窒素 (iNO) は,入院中のCOVID-19患者の健康状態を安全に改善しました. 治療により,補充酸素のない日数が増加し,入院期間が短縮されました.
科学分野:
- 肺医学
- クリティカル ケア 医療
- 感染症
背景:
- 高濃度の吸入された酸化窒素 (iNO) は,上皮細胞におけるSARS-CoV-2の複製を阻害する可能性を示しています.
- iNOは,入院したCOVID-19患者の重篤な疾患の進行を防ぐことができます.
研究 の 目的:
- 入院中のCOVID-19患者の補充酸素に対する160ppmの吸入性窒素酸化物 (iNO) の安全性と有効性を評価する.
- iNOが回復指標と臨床結果に与える影響を評価する.
主な方法:
- 開放式,ランダム化臨床試験は,補充酸素を受けている入院COVID-19患者で実施されました.
- 患者はランダムに分けられ,標準治療または標準治療とiNO (160ppm) を1日6時間受けた.
- 主要な安全性評価は有害事象の発生率であり,次要な有効性評価は15日以内の補充酸素のない日でした.
主要な成果:
- iNOの吸入による有害事象は報告されていません.
- iNOグループは,対照群の8日と比較して,補充酸素なしで平均11日間過ごしました (p=0. 044).
- iNO群では,短期間の入院 (p=0. 004),改善された臨床スコア (p< 0. 05) および呼吸器支援からの離乳率の上昇 (p=0. 005) を含む,著しい改善が観察されました.
結論:
- 吸入された窒素酸化物 (160 ppm) の治療は,入院したCOVID-19患者にとって良好で安全でした.
- iNO療法により,補充酸素を必要としない日数が大幅に増加し,入院期間が短縮され,臨床状態が改善されました.
- iNOは,入院中のCOVID-19患者の管理のための有望な補助療法であることを示唆しています.
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