獣医学におけるチモールの薬物毒性学的側面 体系的なレビュー
Denisa Pérez Gaudio1,2, Mery Giantin3, Marianna Pauletto3
1Laboratorio de Toxicología, Depto. de Fisiopatología, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN), Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina.
Frontiers in veterinary science
|August 28, 2025
まとめ
ティモールは天然の化合物で,動物にとって重要な抗菌および抗炎症効果を示しています. しかし,高用量は特に肝臓と腎臓に毒性があり,安全な獣医用のためにさらなる研究が必要である.
科学分野:
- 獣医薬学
- 毒理学について
- 自然産物
背景:
- エッセンシャルオイルのフェノール化合物であるチモールは,顕著な薬理学的作用を有する.
- 獣医学におけるその潜在的な応用は,既存の研究を全面的に見直す必要がある.
研究 の 目的:
- 動物におけるチモールの薬理学的効果を体系的に評価する.
- 様々な動物モデルでチモールの毒性プロフィールを評価する.
主な方法:
- PRISMA 2020のガイドラインに従って,体系的な文献検索が行われました.
- 検索したデータベースには,PubMed,Scopus,Google Scholar,Web of Science,LILACSが含まれています.
- ティモールの効果と動物に対する毒性に焦点を当てた過去12年間に出版された研究も含まれていた.
主要な成果:
- 特定された1472の記録のうち176の研究が含める基準を満たした.
- ティモールは,広範囲の抗菌,抗ウイルス,抗真菌,抗寄生虫,抗炎症,抗酸化作用を示した.
- 高濃度で主に肝臓と腎臓に影響を与える,用量依存の毒性が観察された.
結論:
- Thymolは,獣医学における治療薬として大きな可能性を秘めています.
- その有益な性質は,用量依存の毒性によって相殺され,慎重に検討する必要があります.
- さまざまな動物種に対する安全で効果的な用量を決定するには,さらなる研究が不可欠です.
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