子供における喘息の流行と危険因子:体系的なレビューとメタ解析
Li Yin1, Feifei Zhang2, Xue Wang1
1Department of Pediatrics, Second Hospital of Hebei Medical University, Shijiazhuang, China.
まとめ
幼児の喘息は11.9%に及ぶ. 重要な危険因子には,特定の化学物質や薬剤への産前暴露,および子供のヘリコバクター・パイロリ感染症が含まれています. 葉酸は保護的かもしれません.
科学分野:
- 小児呼吸器医学
- 環境 健康
- 流行病学
背景:
- 小児性喘息 (CA) は複雑な病因を伴う重大な公衆衛生問題である.
- 有効な予防と管理戦略には 流行とリスク要因の理解が不可欠です
研究 の 目的:
- 幼児喘息の流行を評価するメタ分析を行う.
- 小児性喘息の発症に伴う主要なリスク要因を特定する.
主な方法:
- 2015年から2024年の間に発表された研究の包括的なメタ分析.
- パブ・メッド,エンバース,コクラン,ウェブ・オブ・サイエンスで検索しました.
- 647,414人の参加者を含む45件の研究を対象に,NOSを用いて研究の質を評価し,StataとRを用いてデータを分析した.
主要な成果:
- 小児性喘息の総罹患率は11. 9%でした.
- 特定された危険因子には,ペルおよびポリフルオアルキル物質 (PFAS) の産前暴露 (OR=0. 89),酸抑制薬 (OR=1. 11),および子供のヘリコバクターパイロリ感染症 (OR=2. 07) が含まれる.
- 妊娠中の母親の葉酸補給は,保護的な関連性を示した (OR=1. 18).
結論:
- 小児性喘息の発生率は高いため 特定された危険因子に関するさらなる研究が必要である.
- 胎児の暴露や感染症が 原因であり 葉酸は 保護的かもしれません
- これらの関連性を明らかにするために,さらなる大規模な前向きな研究が推奨されます.
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