関連する実験動画

Updated: Sep 9, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
10:01

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

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質量スペクトロメトリーと機械学習を交互にリンクすることによってトキソプラズマ・ゴンディのインタラクトームのマッピング

Tadakimi Tomita1, Elizabeth Weyer1, Rebekah B Guevara1

  • 1Department of Pathology, Albert Einstein College of Medicine, New York, New York, USA.

mBio
|August 28, 2025
PubMed
まとめ

この研究では,高度なクロスリンク マススペクトロメトリー (XL-MS) と機械学習を用いて,トキソプラズマ・ゴンディの寄生虫のタンパク質相互作用をマッピングしています. この発見により ヒトに広く感染している この病原体に対する 新しい分子詳細と 潜在的な治療標的が明らかになりました

キーワード:
GRA についてトキソプラズマ・ゴンディXL-MS についてインタラクトーム機械学習マススペクトロメトリータンパク質のクロスリンク剤タンパク質とタンパク質の相互作用プロテオミクスリボソーム

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