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Updated: Sep 9, 2025

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins
08:26

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins

Published on: August 31, 2017

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複数の長距離のcis相互作用により,静止状態のHSV-1ゲノムにCTCF分離器依存のウイルスクロマチン領域が生成される

Alyssa Richman1, Sophie Kogut1, Terri Edwards2

  • 1Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.

mBio
|August 28, 2025
PubMed
まとめ

HSV-1 ゲノム内の CCCTC 結合因子 (CTCF) 隔離体は,ウイルスの遺伝子発現を調節するクロマチンのループを組織する. CTRL2分離器を削除すると,この構造が変化し,よりアクセシブルなウイルスゲノムを作り,潜伏期に影響を与えます.

キーワード:
4C-seq についてCCCTCCTCFHSV についてクロマチンエピジェネティック断熱器遅延時間ウイルス隔離剤

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