緩和的な意図による免疫療法に基づく治療法の進行中の治療不能なHNSCC患者における予後要因
Zainab Al Maqrashi1, Michelle Bradbury1, Sze Wah Samuel Chan1
1Department of Oncology, McMaster University, Hamilton, Canada.
Future science OA
|August 28, 2025
まとめ
システム免疫炎症指数 (SII),アルブミン,BMIは,緩和免疫療法を受けている頭頸がん患者の生存率を予測します. これらの安価で非侵襲的な要因は,再発性または転移性疾患の治療決定を導くことができます.
科学分野:
- 腫瘍学
- 免疫療法
- 頭頸部がんの研究
背景:
- 局所的に進行した,切除できない,または転移した頭頸部状細胞癌 (HNSCC) は予後が悪い.
- 先進的なHNSCCでは,緩和的な全身治療の選択肢は限られている.
- 緩和的な意図の免疫療法が 治療の可能性を秘めています
研究 の 目的:
- HNSCCにおける緩和免疫療法に対する好ましい反応に関連する臨床病理学的特徴を特定する.
- 再発性または転移性HNSCC (rmHNSCC) の患者の生存に対する予後要因を評価する.
主な方法:
- rmHNSCCを持つ96人の成人のコホート研究.
- 収集されたデータ:人口統計,疾患の特徴,治療,結果 (2018年1月〜2022年12月).
- 予後要因を特定するために実施された単変量および多変量分析.
主要な成果:
- 全生存期間の中央値は12. 6ヶ月で,中央値は5. 3ヶ月でした.
- システム免疫炎症指数 (SII),アルブミン,体量指数 (BMI) は独立して生存の有意な予後要因であった.
- 大多数の患者はプラチナ不適格または耐火症 (61. 5%) でした.
結論:
- SII,アルブミン,BMIは,緩和免疫療法を受けているrmHNSCC患者の全生存期における強力な独立した予後要因である.
- これらの安価で非侵襲的な要因は 修正可能であり 治療戦略を導きます
- これらの発見を裏付けるためのさらなる検証研究は必要である.
さらに関連する動画
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.6K
06:11Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
9.9K
関連する概念動画
Tumor Immunotherapy
659
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
659
Cancer Vaccines
509
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
509
Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
