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研究分野生物医学と臨床科学腫瘍学とがん発生予測・予測マーカー
保存されたFABP5^高マクロファージサブセットは,進行性肝疾患における線維症と発がんを促進する.

保存されたFABP5^高マクロファージサブセットは,進行性肝疾患における線維症と発がんを促進する.

Wenhao Ge ^1,2, Lifeng Ma ^3,4, Yu Huang ^1,2, Weigao E ^3,4, Shujing Lai ⁵, Bijun Cui ², Jingjing Wang ^3,4, Yutian Ji ^1,2, Daiyuan Liu ^3,4, Song Ye ¹, Yang Kong ¹, Jiarong Zhou ^1,2, Chengxuan Yu ⁶, Yingsheng Wu ¹, Qiang Sun ¹, Dongkai Zhou ¹, Wei Zhu ², Yuan Ding ^1,2,7,8,9,10, Xiaoping Han ^3,4, Guoji Guo ^3,4, Weilin Wang ^1,2,7,8,9,10

Wenhao Ge ^1,2, Lifeng Ma ^3,4, Yu Huang ^1,2

¹Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
²Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, China.
³Bone Marrow Transplantation Center of the First Affiliated Hospital, and Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
⁴Liangzhu Laboratory, Zhejiang University, Hangzhou, China.
⁵Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁷Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Hangzhou, China.
⁸National Innovation Center for Fundamental Research on Cancer Medicine, Hangzhou, China.
⁹Cancer Center, Zhejiang University, Hangzhou, China.
¹⁰ZJU-Pujian Research & Development Center of Medical Artificial Intelligence for Hepatobiliary and Pancreatic Disease, Hangzhou, China.

⁰Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Liver International : Official Journal of the International Association for the Study of the Liver +

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2025年8月28日

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PubMedで要約を見る

まとめ

この要約は機械生成です。

この研究は正常な肝細胞が癌細胞に変容する方法を明らかにしマクロファージと内皮細胞の特定のサブセットを特定し肝繊維症と癌の進行を促していますこれらの発見は肝臓がんの新しい標的治療法への道を開きます

科学分野

細胞・分子生物学
癌研究
ヘパトロジー

背景

慢性肝疾患から肝がんへの進行は完全に理解されていません.
進行した肝疾患の治療法は限られています.

研究の目的

肝臓病の進行中の細胞と分子の変化をマッピングする
正常な肝臓から病気の肝臓への進化を理解するために

主な方法

肝臓の正常細胞,肝硬変細胞,がん細胞の 13万以上の単細胞RNA配列解析
腫瘍の異質性と微小環境を評価するためのバイオインフォマティクス分析
インビトロとインビボの分子生物学的検証

主要な成果

肝臓細胞がん (HCC) と肝臓内胆管がんの異質性の詳細なプロファイリング.
FABP5が高く,繊維症や癌を誘発するマクロファージを特定し,その役割は保存される.
HCCにおけるRGCC+COL4A1+内皮細胞の発見は,がん細胞の侵入と増殖を促す可能性がある.

結論

肝臓がんの進化の経路について重要な洞察を得ました
新しい細胞サブセットベースの免疫療法と肝臓がんの標的治療の可能性を強調しています.

キーワード:

FABP5 について免疫細胞肝臓がん腫瘍の微小環境

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