関連する実験動画

Updated: Jun 20, 2026

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

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MuST:単細胞空間トランスクリプトミクスのための多様性構造変換

Zelin Zang1,2, Liangyu Li1, Yongjie Xu1

  • 1Westlake Institute for Advanced Studies, Westlake University, HangZhou, 310000, China.

Briefings in bioinformatics
|August 28, 2025
PubMed
まとめ

空間トランスクリプトミクス (ST) のデータは,支配的モダリティによってバイアスされる可能性があります. 多様性の構造変換 (MuST) を開発し 複雑な生物学的システムの 組織構造とバイオマーカー分析を 統合しました

キーワード:
バイオマーカーの識別モダリティーバイアスマルチモダリティ統合空間トランスクリプトミクス (ST)トポロジーの発見

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Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies05:45

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Chromatin Structure and RNA Splicing

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The chromatin structure, especially...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Master Transcription Regulators02:23

Master Transcription Regulators

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