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Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.2K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Rolling Resistance01:21

Rolling Resistance

351
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down...
351
Rolling Without Slipping01:09

Rolling Without Slipping

4.2K
People have observed the rolling motion without slipping ever since the invention of the wheel. For example, one can look at the interaction between a car's tires and the surface of the road. If the driver presses the accelerator to the floor so that the tires spin without the car moving forward, there must be kinetic friction between the wheels and the road's surface. If the driver slowly presses the accelerator, causing the car to move forward, the tires roll without slipping. It is...
4.2K
Patterns of Fever01:26

Patterns of Fever

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Before understanding the types and patterns of fever, it is essential to know its phases.
3.0K
Force and Momentum01:17

Force and Momentum

16.1K
Force and momentum are intimately related. Force acting over time can change momentum, and Newton's second law of motion can be stated in its most broadly applicable form in terms of momentum. Momentum can be applied to systems where the mass is changing, such as rockets, as well as to systems of constant mass. Also, momentum continues to be a key concept in the study of atomic and subatomic particles in quantum mechanics. One can consider systems with varying mass in some detail; however,...
16.1K
Resistance01:19

Resistance

4.6K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
4.6K

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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis EAE Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis EAE Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

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容赦ない

Sarah Martin Reel1

  • 1Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

JAMA oncology
|August 28, 2025
PubMed
まとめ

No abstract available in PubMed .

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Last Updated: Sep 9, 2025

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