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Updated: Sep 9, 2025

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
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Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

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SwsBはBacillus subtilisのムラミック・δ-ラクトーム・サイクラゼとして作用する スポア・ペプチドグリカン合成

Madison E Hopkins1, Zachary Yasinov1, Mark J Fakler1

  • 1Chemistry Department, Hamilton College, Clinton, New York 13323, United States.

Biochemistry
|August 28, 2025
PubMed
まとめ

バクテリアの胞子酵素SwsBは,胞子発芽に不可欠なムラミック-δ-ラクタムの合成に不可欠です. この研究は,SwsBが,エネルギー投入なしにラクトーム形成を触媒化する,デセチラゼではなく,ユニークなサイクラゼとして機能することを明らかにしています.

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