関連する実験動画

Updated: Sep 9, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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セリアック病におけるトランスグルタミンゼ2媒介のグルテン抗原の表示に責任を持つデンドリート細胞群

Fu-Chen Yang1, Harrison A Besser1, Hye Rin Chun2

  • 1Department of Chemistry, Stanford University, Stanford, United States of America.

JCI insight
|August 28, 2025
PubMed
まとめ

デンドリット細胞 (DCs) はトランスグルタミナーゼ2 (TG2) とLRP1を使用して,グルテン抗原をセリアック疾患 (CeD) で処理する. この経路はヒト単細胞で活性化され,CeD患者で上昇し,グルテン毒性の細胞基盤を明らかにします.

キーワード:
アンチゲン自己免疫性デンドリット細胞胃腸内科MHCクラス2

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