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Updated: Sep 9, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

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FUSE-PhyloTree: タンパク質ファミリーの関数と配列保存モジュールを,系統分析によって結合する

Olivier Dennler1,2, Elisa Chenel1, François Coste1

  • 1Univ Rennes, Inria, CNRS, IRISA, UMR 6074, Rennes, France.

Bioinformatics (Oxford, England)
|August 28, 2025
PubMed
まとめ

FUSE-PhyloTreeソフトウェアは,タンパク質機能に関連する配列保存を特定します. 配列分析と系統遺伝学を組み合わせて,タンパク質ファミリー内の機能的進化をマッピングしています.

キーワード:
多重シーケンスアライナメント系統遺伝学タンパク質ドメインタンパク質の進化タンパク質の機能

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
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