ポリオの生存者におけるサブ臨床的視覚経路機能障害の証拠:視覚誘発の可能性に関する研究
まとめ
ポリオを生き延びた人は,視界回転誘発ポテンシャル (PRVEP) の幅度が低下し,サブクリニックの視界経路の問題を示しています. この機能障害はポリオの生存者における疲労の重さとは関係ありません.
科学分野:
- 神経科学
- 眼科について
- 神経学
背景:
- 脊髓灰質炎は 長期にわたる 神経学的後遺症を引き起こす可能性があります
- 視覚経路の機能不全はポリオの生存者に起こることがあります.
- サブクリニカルな視覚異常は,この集団で十分に特徴づけられていない.
研究 の 目的:
- ポリオの生存者における視覚誘発潜在 (VEP) 異常を評価する.
- サブクリニカル視覚経路機能障害の指標としてVEPを特定する.
- 視覚皮質の興奮と疲労の重度の関係を調べる
主な方法:
- 30人のポリオ生存者と30人の対照群を比較した.
- パターン逆転 (PRVEP) とフラッシュ VEP (FVEP) を実施した.
- 疲労度スケール (FSS) は,PSで評価された疲労.
主要な成果:
- PSは,コントロールと比較して,PRVEPでP100の幅を大幅に減少させた.
- FVEPの幅とVEPの遅延は,グループ間で比較可能でした.
- PSにおけるFSSスコアとVEPパラメータとの間には相関関係が見つかりませんでした.
結論:
- PRVEPの振幅の減少は,PSにおける中央視構造のサブ臨床的関与を示唆する.
- これらの視覚経路の変化は主観的な疲労とは無関係です.
- VEPの異常はポリオ後の視覚障害のバイオマーカーとして機能する.
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