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Electrophilic Aromatic Substitution: Nitration of Benzene01:20

Electrophilic Aromatic Substitution: Nitration of Benzene

6.4K
The nitration of benzene is an example of an electrophilic aromatic substitution reaction. It involves the formation of a very powerful electrophile, the nitronium ion, which is linear in shape. The reaction occurs through the interaction of two strong acids, sulfuric and nitric acid.
6.4K
Nitrosation of Enols01:19

Nitrosation of Enols

3.8K
The nitrosation reaction is one of the methods of preparing 1,2-diketones. The enol tautomer of the starting ketone reacts with sodium nitrite in hydrochloric acid, generating the 1,2-diketone after hydrolysis.
3.8K
Preparation of Nitriles01:12

Preparation of Nitriles

2.2K
One of the common methods to prepare nitriles is the dehydration of amides. This method requires strong dehydrating agents like phosphorous pentoxide or boiling acetic anhydride for converting amides to nitriles. Another reagent namely, thionyl chloride also accomplishes the dehydration of amides, where amide acts as a nucleophile. The first step of the mechanism involves the nucleophilic attack by the amide on the thionyl chloride to form an intermediate. In the next step, the electron pairs...
2.2K
2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

4.6K
Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
4.6K
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism01:37

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

4.0K
Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
4.0K
Nitriles to Ketones: Grignard Reaction00:57

Nitriles to Ketones: Grignard Reaction

4.8K
Organomagnesium halides, commonly known as Grignard reagents, convert nitriles to ketones and proceed through a nucleophilic acyl substitution. Nitriles react with a Grignard reagent, followed by an aqueous acid, to yield ketones. The reaction introduces a new carbon–carbon bond. The alkyl–magnesium bond in the Grignard reagent is highly polar, so the alkyl carbon develops a carbanionic character and acts as a nucleophile.
The mechanism begins with a nucleophilic attack by the Grignard...
4.8K

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Updated: Sep 9, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

8.2K

チップ誘発ナイトレン生成

Leonard-Alexander Lieske1, Aaron H Oechsle1, Igor Rončević2

  • 1IBM Research Europe - Zurich, Rüschlikon 8803, Switzerland.

ACS nano
|August 28, 2025
PubMed
まとめ
この要約は機械生成です。

研究者は3つの反応性ナイトレンセンターを持つ 新種の分子 トリニトレノ-s-ヘプタジンを作りました この高スピンの分子は 独特の磁気特性を表しており 特定の条件下でセプテットからセクステットの基本状態に 移行します

キーワード:
原子力顕微鏡コンピュータ化学ニトロンの化学表面合成チップ誘発化学

さらに関連する動画

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

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Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

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Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
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科学分野:

  • * 表面科学
  • * 分子化学
  • * 量子磁気

背景:

  • * 複数のニトロンの中心を持つ分子は,そのユニークな電子および磁気特性のために興味があります.
  • * 尖端誘発化学は,新しい分子構造の表面合成のための経路を提供します.
  • このようなシステムのスピン状態と磁気結合の理解は,潜在的なアプリケーションにとって極めて重要です.

研究 の 目的:

  • * 三酸化窒素中心の分子を合成し,特徴づけること.
  • * 分子の磁気結合と基底状態の回転を調査する.
  • * 表面環境が分子の性質に及ぼす影響を調べる

主な方法:

  • * NaCl/Au111) の表面で尖端誘導化学を用いた表面合成
  • * 原子力顕微鏡 (AFM) とスキャニングトンネル顕微鏡 (STM) を用いた特徴付け
  • * 断交対称性密度関数理論 (DFT) と構成相互作用 (CI) を含む理論的計算

主要な成果:

  • * トリアジド前駆体からモノ-, ディ-, トリニトレノ- s- ヘプタジンの生成を成功させた.
  • * 1〜3つの窒素中心を持つ分子形成の実験的証拠
  • * ガス相における高スピンセプテットの基底状態につながる,鉄磁気結合の理論的予測.
  • * NaCl/Au111) 表面におけるトリニトレノ-s-ヘプタジンに対するアニオンセクステット基底状態の実験的および理論的指標.

結論:

  • * トリニトレノ-s-ヘプタジンは,尖端誘導化学により表面で合成することができる.
  • * 分子は,その環境 (ガス相対表面) に依存する調節可能な磁気特性を示します.
  • * この研究は,表面上の高スピン分子の合成と磁気行動に関する洞察を提供します.