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Updated: Sep 9, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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ユカリオットタンパク質品質管理の中心となる巨大なE4リガゼであるUBR4複合体の構造

Daniel B Grabarczyk1, Julian F Ehrmann1,2, Paul Murphy1

  • 1Research Institute of Molecular Pathology, Vienna BioCenter (VBC), Vienna, Austria.

Science (New York, N.Y.)
|August 28, 2025
PubMed
まとめ

研究者らはUBR4 E4リガゼメガ複合体の構造を明らかにし,有毒なタンパク質の集積物を排除するために決定的な役割を果たしました. この複合体は 損傷したタンパク質を分解し 細胞の健康と機能を維持します

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