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Updated: Sep 9, 2025

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進行性多発性硬化症では状繊維酸性タンパク質が上昇する

Luke A Schwerdtfeger1, Federico Montini1,2, Martina Antonini Cencicchio2

  • 1Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Neurology(R) neuroimmunology & neuroinflammation
|August 28, 2025
PubMed
まとめ

進行性多発性硬化症 (MS) の患者では,状繊維酸性タンパク質 (GFAP) のレベルが高く,疾患悪化の予後生物マーカーである可能性を示唆しています.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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