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アトランティック・フォレストからの菌類の生物多様性皮膚性リーシュマニア症に対する生物活性代謝物質

Juliana Cristina Pereira Calado¹, Marina Valente Navarro¹, Alison Felipe Alencar Chaves¹

¹Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, Sao Paulo, Brazil.

Chemistry & biodiversity

|August 28, 2025

まとめ

新しいアスペルギルス・フミガトゥス抽出物 (I06) は,ライシュマニアの寄生虫に対する強力な活性を示し,マウスの感染と病変を軽減します. この発見により微生物の生物多様性は新しいリーシュマニア症の治療法の有望な源となるのです

科学分野:

微生物学
寄生虫学
薬物の発見

背景:

生物多様性は新しい生物活性化合物を特定するための重要な資源です.
リーシュマニア症は世界的に大きな健康問題であり新しい治療戦略が必要です

研究の目的:

アスペルギルス・フミガタスの抽出物の抗リーシュマニア作用を調べる
Leishmania amazonensisに対する有望な抽出物の有効性と安全性を評価する.

主な方法:

環境サンプルからアスペルギルス・フミガタスの分離
マクロファージにおけるLeishmania (Leishmania) amazonensisに対する原料の試験
液体クロマトグラフィー-質量スペクトロメトリー部品の識別
寄生虫の生存能力,アポトーシスマーカー,そして反応性酸素種の評価.
ネズミモデルでの in vivo 効果と安全性に関する研究

主要な成果:

抽出物I06は,マクロファージの寄生虫負担と感染率の有意な減少を示し,IC50は1μg/ mlであった.
I06はレイシュマニアの寄生虫で遅いアポトーシスを誘発し,反応性酸素種を急速に増加させた.
抽出物は, in vitro と in vivo で非血分解性であった.
感染したマウスの内投与により,病変のサイズと寄生虫の量が減少した.

結論:

アスペルギルス・フミガトゥス抽出物I06は,安全性プロファイルを持つ強力な抗リーシュマニア剤です.
I06はリーシュマニア症の有望な治療候補である.
微生物の生物多様性は新薬の発見のための貴重な貯蔵庫です

キーワード:

リーシュマニア (Leishmania) アマゾンネシス生物活性化合物生物多様性

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