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Updated: Sep 9, 2025

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
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プラシノスタットは,miR-381-3p/ MDM2軸を標的とし,p53信号経路を活性化することで,臓がんの悪質な生物学的行動を抑制する

Dongyun Cun1, Feng Liu1, DaGuang Tian1

  • 1Department of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital of Kunming Medical University, China.

Pathology, research and practice
|August 28, 2025
PubMed
まとめ

アセチラーゼ阻害剤であるプラシノスタットは,MDM2を抑制しながら,miR- 381 - 3pとp53を上調することで,臓がんの成長を抑制する. このメカニズムは癌細胞の増殖と移動を阻害し 治療戦略の可能性を秘めています

キーワード:
p53 ユビキチネーションの分解MDM2 についてMiR-3813p臓がんプラクチノスタット

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