皮膚の老化の臨床評価:体系的なレビュー
Yu-Ching Wang1, Sheng-Hsiang Ma2, Yun-Ting Chang3
1Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Archives of gerontology and geriatrics
|August 28, 2025
まとめ
この体系的なレビューでは皮膚の老化を評価するスケールが評価されます. 大抵の検証されたスケールでは,や脱落や質感の分類に優れた信頼性があり,皮膚の老化を客観的に評価するのに役立ちます.
科学分野:
- 皮膚科と美学科学
- バイオ統計学とサイコメトリック
背景:
- 皮膚の老化は複雑な生物学的プロセスで 肌のしわやや色素の喪失などの 変化が目に見えてきます
- 皮膚の老化の客観的な評価は研究と臨床の実践にとって極めて重要ですが,既存の評価ツールには品質と有効性が異なっています.
研究 の 目的:
- 皮膚の老化を評価するための既存の尺度や器具を体系的に検討し,検証する.
- 様々な皮膚老化評価指標の信頼性と一致性を評価する.
主な方法:
- MEDLINE (PubMed),EMBASE,およびコクランデータベースの体系的な文献検索
- 皮膚の老化に関する47の異なるスケールを分析した42の出版物が含まれています.
- スケールの分類は,格付けライン/しわ,収縮/体積損失,質感/品質,および全体的な評価です.
主要な成果:
- 大抵の個別のスケールでは,許容可能な合意の強さを示した.
- 大半のスケールは,少なくとも適度な評価者間および評価者内信頼性を達成した.
- 検査した器具は,質感,弾性,収縮,変色,構造的整合性,バリア機能を含むパラメータを定量化しました.
結論:
- 皮膚の老化を評価するための検証されたスケールは,一般的に許容可能な信頼性を持っています.
- レビューされたスケールは,年齢に関連する皮膚変化の客観的で再現可能な評価のための基礎を提供します.
- 皮膚の老化を評価するための新しい定量的なツールを開発し,既存のツールを改良する研究が進められるでしょう.
関連する概念動画
Renewal of Skin Epidermal Stem Cells
3.3K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.3K
The Effect of Aging on Tissues
4.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.2K
Changes in Skin Color: Clinical Perspectives
4.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.2K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
817
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
817
Pharmacodynamics in Geriatric Patients: Effects of Age
339
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
339
Aging
1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K


