関連する実験動画
Updated: Sep 9, 2025

14:56
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
21.5K
労働中の感覚喪失のパターンの特徴: 副鼻腔鎮痛: 突破性痛みの将来的な研究
L Kordich1, J P Ghiringhelli1, R B George1
1Department of Anesthesiology and Pain Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Canada.
International journal of obstetric anesthesia
|August 28, 2025
まとめ
氷の感覚による出産後の外周麻酔の評価は,突破性痛みの時にT10以下で完全な感覚喪失を効果的に特定します. 鎮痛剤の回復は,このレベルをT10以上に引き上げ,痛みの管理を最適化します.
科学分野:
- 麻酔学と痛み管理
- 産婦人科
背景:
- 出産中の外経鎮痛は,完全および部分的な2つの異なるレベルで,頭蓋骨の感覚喪失を評価することを含む.
- 出産時の突破性痛は epidural analgesia の不十分な拡散と関連付けられる.
研究 の 目的:
- 患者に痛みが突入する際に, 産後の外周麻酔で, 完全または部分的な感覚喪失のレベルを決定する.
- 効果的鎮痛薬が回復した後,これらの感覚喪失のレベルがどのように変化するか評価する.
主な方法:
- 探索的な前向きなコホート研究が行われました.
- 30人の分娩中の患者で,痛みの突破口と鎮痛回復後に,氷と針刺しによる感覚喪失のレベル (完全または部分) を評価した.
主要な成果:
- 痛みの時のT12から鎮痛が回復した後のT10に増加した.
- 痛みの時のT12から,鎮痛が回復した後のT11に増加した.
- アナルジェシア補充前と後,氷と針刺しによる部分的な感覚喪失は一貫してT10以上でした.
結論:
- 突破性出産の痛みの患者は T10以下で 完全な感覚喪失を示します
- 疼痛緩和後のT10またはそれ以上の増加を示す氷の感覚評価は,出産後の epidural analgesiaの有効性を評価するために好ましいかもしれません.
- 出産後の外周麻酔の最適化は,氷に対する完全な感覚喪失を監視することによって達成することができる.
関連する概念動画
Local Anesthetics: Clinical Application as Epidural Anesthesia
498
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
498
Local Anesthetics: Differential Sensitivity of Nerve Fibers
929
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
929
Analgesia and Pain Management
788
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
788
Local Anesthetics: Clinical Application as Spinal Anesthesia
772
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
772
Opioid Analgesics: Synthetic and Semisynthetic Opioids
421
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
421
Local Anesthetics: Adverse Effects
491
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
491

