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Updated: Sep 9, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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複製タンパク質Aの欠陥による非阻害性アゾオスペミアを引き起こす化合物ヘテロジゴスDMC1変種

Yan Wang1, Renxue Wang1, Ziyou Bao1

  • 1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention (Under Construction), Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China.

Reproductive biomedicine online
|August 28, 2025
PubMed
まとめ

新しい化合物ヘテロジゴス型DMC1変異体は,メオシスを妨害することによって非阻害性アゾオスペミアを引き起こす. これはDmc1ノックアウトマウスで確認された 欠陥DNA修復と同質ペアリングにつながる.

キーワード:
複合性ヘテロジゴス型DMC1 について男性不妊症RPAの累積精子発生停止

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