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Updated: Sep 9, 2025

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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口腔状細胞がんの発達と免疫療法におけるPAK5の役割とメカニズム

Yuchen Qi1, Jie Mou2, Jiadong Huang3

  • 1The Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou 221000, China; School of Stomatology, Xuzhou Medical University, Xuzhou 221000, China.

International immunopharmacology
|August 28, 2025
PubMed
まとめ

この研究では,PAK5の過剰発現が口腔状細胞癌 (OSCC) の進行と免疫療法への抵抗を誘発することを明らかにした. PAK5阻害剤とペムブロリズマブを併用すると,免疫抑制性腫瘍微環境 (TME) の改造により,腫瘍を効果的に減少させる.

キーワード:
免責権口腔状細胞がんPAK5 についてペムブロリズマブ治療

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