主要な運動皮質の姿勢サブスペース

Patrick J Marino¹, Lindsay Bahureksa², Carmen Fernández Fisac²

¹Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA.

Neuron

|August 28, 2025

まとめ

脳は運動の目標と身体の姿勢を運動皮質 (M1) で組み合わせる. 研究者達はこれらの信号が独立した正交の神経空間に編成されていることを発見し柔軟な行動生成を可能にしました

科学分野:

神経科学
モーターコントロール
計算神経科学

背景:

脳は動きの目標と身体の姿勢の情報を統合して行動を起こすのです
主要な運動皮質 (M1) は,この統合のための重要な脳の領域です.
M1がこれらのシグナルをどのように組織するかを理解することは,柔軟な運動制御を説明する鍵です.

研究の目的:

主要運動皮質 (M1) 内の姿勢と運動の目標信号の組織を調査する.
M1アクティビティが,さまざまな身体姿勢で,どのように柔軟に動作コマンドを生成するかを決定する.

主な方法:

猿の原発運動皮質 (M1) の神経活動が記録された.
猿は様々な姿勢で前腕の動きを含む様々な作業を行いました
姿勢と目標に関連する要素を特定するために神経集団の活動を分析した.

主要な成果:

姿勢と目標の信号は,M1ニューラル集団の活動内で分離可能であることが判明した.
これらの信号はほぼ直角のサブスペースを占め, 明確な組織原理を示しています.
M1における姿勢信号の組織は,異なるタスクにおいて安定していた.
特定の運動目標のための神経軌跡は各タスク内の様々な姿勢で類似した形状を示しました

結論:

M1は,これまで理解していたよりも,より単純な姿勢信号の組織を示しています.
M1における姿勢とゴールシグナルの区切りは,それらの柔軟な組み合わせを容易にする.
この組織は脳の様々な行動を生み出す能力を支えています

キーワード:

脳とコンピュータのインターフェース脳と機械のインターフェース次元縮小運動皮質ニューラル集団の動態姿勢自己受容センサー・モーター統合

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