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Updated: Sep 9, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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SOX4-セマフォリン3C軸は食道腺がんの進行を促進する

Tala Fnu1, Peiguo Shi2, Wanwei Zhang3

  • 1Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Cancer letters
|August 28, 2025
PubMed
まとめ

SOX4は転写因子であり,セマフォリン3C (SEMA3C) を調節することによって食道腺がん (EAC) の進行を誘導する. この経路をターゲットにすることで この攻撃的な癌の 新しい治療戦略が生まれます

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