関連する実験動画

Updated: Sep 9, 2025

Single-Molecule FRET Imaging for Observing the Conformational Dynamics of Dynamin-Like GTPase Atlastin
10:19

Single-Molecule FRET Imaging for Observing the Conformational Dynamics of Dynamin-Like GTPase Atlastin

Published on: January 24, 2025

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モノメア ATP9A フリッパースの冷凍-EM 構造によって明らかになったユニークなゲートメカニズム

Kazuhiro Abe1, Parthiban Marimuthu2, Yuheng Qian3

  • 1Department of Chemistry, Faculty of Science, Hokkaido University, Japan.

The Journal of biological chemistry
|August 28, 2025
PubMed
まとめ

哺乳類のATP9Aは,他のP型ATPアゼとは異なり,TM6-10ヘリキスを用いて独特のゲートフォスホリピドをフリップする. このユニークなメカニズムは,より大きなフォスフォリピドの結合を可能にし,負の電荷を持つ脂質でATPaseの活性を増強します.

キーワード:
アトピーゼクリオ電子顕微鏡脂質輸送膜タンパク質分子ダイナミクスシミュレーションフォスフォリピド輸送機

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