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Updated: Sep 9, 2025

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

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T2リラクソメトリーを用いた無形固体分散における活性薬剤の結晶性の定量評価

Tsunenobu Katsumata1, Hiromu Taguchi2, Yusuke Minamino2

  • 1Formulation Development Department, Development & Planning Division, Nichi-Iko Pharmaceutical Co., Ltd., 205-1 Shimoumezawa, Namerikawa, Toyama, 936-0857, Japan.

Journal of pharmaceutical sciences
|August 28, 2025
PubMed
まとめ

この研究では,固体分散 (SD) の活性薬剤成分 (API) の結晶性を定量化するための新しい方法として,時間領域 NMR T2 リラクソメトリを導入しています. この技術はAPIの結晶性を正確に測定し,従来の方法に価値のある代替手段を提供します.

キーワード:
結晶度定量的な評価固体分散(2) リラクソメトリータイムドメイン NMR変形する

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