化学工場の労働者の生物学的老化の加速
Zhiguang Gu1, Liming Zhang2, Xiangkai Zhao1
1Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Environmental research
|August 28, 2025
まとめ
焦炭炉の排出物 (COEs),ベンゼン,石炭粉への職業的曝露は生物学的老化を加速し,特に若い労働者の心血管と代謝の健康に影響します. リスクの高い産業では 厳格な安全対策が不可欠です
科学分野:
- 労働衛生について
- 毒理学について
- ゲロントロジー
背景:
- 化学薬品への職業的曝露と生物学的老化との関連は十分に確立されていません.
- この研究では,コックスオーブン排出量 (COEs),ベンゼン,メタノール,石炭粉と労働者の加速された生物学的老化との関連を調査しています.
研究 の 目的:
- 特定の職業上の化学物質の曝露と生物学的老化メトリックの関係を調べる.
- どの化学物質の曝露が 加速された老化と最も強く関連しているかを特定する.
主な方法:
- 中国の化学工場で働く2621人の労働者が職業上の被曝を評価した.
- 生物学的年齢加速 (KDM-BAacc,免疫BAacc,心臓代謝BAacc,肝臓-腎臓BAacc) は,KlemeraとDoubalの方法 (KDM) を用いて10の生物医学指標に基づいて計算された.
- 一般的線形回帰モデルは,被曝グループと生物学的年齢指標の関連性を分析した.
主要な成果:
- COE,ベンゼン,石炭粉への曝露は,対照群と比較してKDM-BAaccと心臓代謝-BAaccを有意に増加させた.
- 関連性は若い労働者 (18歳から44歳) で顕著で,女性ではより顕著でした.
- 性別とCOEの曝露の間の有意な相互作用が観察されました.
結論:
- COE,ベンゼン,石炭粉への職業的曝露は生物学的老化を加速し,心血管と代謝システムに影響を与えます.
- 化学薬品への曝露リスクが高い産業における労働安全衛生の監視の強化の必要性を強調しています.
- 早期老化を防止し,労働者の健康を改善することは,公衆衛生の重要な目標です.
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