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Updated: Sep 9, 2025

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

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SYVN1-EGFR軸をターゲットに:TKI耐性NSCLCに対する画期的な戦略

Xinsheng Xie1,2,3, Weilai Tong3,4, Yue Xie5

  • 1Department of Orthopedic Surgery, The Third Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Cell death & disease
|August 28, 2025
PubMed
まとめ

シノビオリン-1 (SYVN1) はEGFRを安定させることで,非小細胞肺がん (NSCLC) の成長を促します. LS-102でSYVN1を標的にすると,NSCLCの治療においてAZD9291のようなEGFR- TKIsに対する抵抗を克服することができる.

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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure09:38

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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib09:38

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

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